Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies

Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies

Abstract VEGFR2 and FAK signaling pathways are interconnected and have synergistic effects on tumor angiogenesis, growth, and metastasis. Thus, instead of the conventional targeting of each of these proteins individually with a specific inhibitor, the present work aimed to discover novel dual inhibi...

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Bibliographic Details
Main Authors: Marwa A. Fouad, Alaa A. Osman, Noha M. Abdelhamid, Mai W. Rashad, Ashrakat Y. Nabawy, Ahmed M. El Kerdawy
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Chemistry
Subjects:
Pharmacophore modelling
Virtual screening
Molecular docking
Cancer
FAK
VEGFR2
Online Access:https://doi.org/10.1186/s13065-024-01130-5

Internet

https://doi.org/10.1186/s13065-024-01130-5

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