LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer

LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer

Abstract Background Long Interspersed Nuclear Element-1 (LINE-1, L1) is increasingly regarded as a genetic risk for lung cancer. Transcriptionally active LINE-1 forms a L1-gene chimeric transcript (LCTs), through somatic L1 retrotransposition (LRT) or L1 antisense promoter (L1-ASP) activation, to pl...

Full description

Bibliographic Details
Main Authors: Zeguo Sun, Rui Zhang, Xiao Zhang, Yifei Sun, Pengpeng Liu, Nancy Francoeur, Lei Han, Wan Yee Lam, Zhengzi Yi, Robert Sebra, Martin Walsh, Jinpu Yu, Weijia Zhang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Molecular Cancer
Subjects:
LINE-1
Transposable element
NSCLC
LUSC
LUAD
FGGY
Online Access:https://doi.org/10.1186/s12943-022-01618-5

Internet

https://doi.org/10.1186/s12943-022-01618-5

Similar Items