Production of high loading insulin nanoparticles suitable for oral delivery by spray drying and freeze drying techniques
Abstract Insulin nanoparticles (NPs) with high loading content have found diverse applications in different dosage forms. This work aimed to evaluate the impact of freeze-drying and spray drying process on the structures of insulin-loaded chitosan nanoparticles, with or without mannitol as cryoprote...
Main Authors: | Yigong Guo, Alberto Baldelli, Anika Singh, Farahnaz Fathordoobady, David Kitts, Anubhav Pratap-Singh |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-06-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-13092-6 |
Similar Items
-
Concept for a Unidirectional Release Mucoadhesive Buccal Tablet for Oral Delivery of Antidiabetic Peptide Drugs Such as Insulin, Glucagon-like Peptide 1 (GLP-1), and their Analogs
by: Anubhav Pratap-Singh, et al.
Published: (2023-09-01) -
Mercaptonicotinic acid activated thiolated chitosan (MNA-TG-chitosan) to enable peptide oral delivery by opening cell tight junctions and enhancing transepithelial transport
by: Anubhav Pratap-Singh, et al.
Published: (2023-10-01) -
Spray Freeze Dried Lyospheres<sup>®</sup> for Nasal Administration of Insulin
by: Tuğrul Mert Serim, et al.
Published: (2021-06-01) -
Dual and triple encapsulated iron gluconate speed up anemia recovery in an animal model
by: Alberto Baldelli, et al.
Published: (2023-12-01) -
Plant Extracts Containing Saponins Affects the Stability and Biological Activity of Hempseed Oil Emulsion System
by: Maciej Jarzębski, et al.
Published: (2020-06-01)