The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation

The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation

Background: Angiopoietin-like protein 8 (ANGPTL8) is known to regulate lipid metabolism and inflammation. It interacts with ANGPTL3 and ANGPTL4 to regulate lipoprotein lipase (LPL) activity and with IKK to modulate NF-κB activity. Further, a single nucleotide polymorphism (SNP) leading to the ANGPTL...

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Bibliographic Details
Main Authors: Mohamed Abu-Farha, Dhanya Madhu, Prashantha Hebbar, Anwar Mohammad, Arshad Channanath, Sina Kavalakatt, Nada Alam-Eldin, Fatima Alterki, Ibrahim Taher, Osama Alsmadi, Mohammad Shehab, Hossein Arefanian, Rasheed Ahmad, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
ANGPTL8
TNFα
NF-κB
glucose metabolism
single nucleotide polymorphism
Online Access:https://www.mdpi.com/2073-4409/12/21/2563

Internet

https://www.mdpi.com/2073-4409/12/21/2563

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