Tumor Microenvironment Responsive Nanomicelle with Folic Acid Modification Co-Delivery of Doxorubicin/Shikonin for Triple Negative Breast Cancer Treatment

Tumor Microenvironment Responsive Nanomicelle with Folic Acid Modification Co-Delivery of Doxorubicin/Shikonin for Triple Negative Breast Cancer Treatment

Triple negative breast cancer (TNBC), which has poor prognosis, easily develops drug resistance and metastasizes. In general, those TNBC characteristics are related to a high activation of the epithelial-mesenchymal transition (EMT) pathway, which is inhibited by shikonin (SKN). Therefore, the syner...

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Bibliographic Details
Main Authors: Wu Zhong, Zhehao Shen, Menglan Wang, Hongyi Wang, Yuting Sun, Xiaojun Tao, Defu Hou
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceuticals
Subjects:
nanomicelles
doxorubicin
shikonin
tumor microenvironment-sensitive
TNBC
targeted therapy
Online Access:https://www.mdpi.com/1424-8247/16/3/374

Internet

https://www.mdpi.com/1424-8247/16/3/374

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