Cell-permeable peptide nucleic acid antisense oligonucleotide platform targeting human betacoronaviruses

Cell-permeable peptide nucleic acid antisense oligonucleotide platform targeting human betacoronaviruses

IntroductionAntisense oligonucleotides (ASOs) with therapeutic potential have recently been reported to target the SARS-CoV-2 genome. Peptide nucleic acids (PNAs)-based ASOs have been regarded as promising drug candidates, but intracellular delivery has been a significant obstacle. Here, we present...

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Bibliographic Details
Main Authors: Soree Park, Seong Ho Kim, Mehrangiz Dezhbord, Eun-Hwi Lee, Yeasel Jeon, Daram Jung, Se Hun Gu, Chiho Yu, Seung Ho Lee, Sung Chun Kim, Kyun-Hwan Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Microbiology
Subjects:
SARS-CoV-2
antisense oligonucleotide
human betacoronavirus
modified PNA
cell-permeable peptide nucleic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1258091/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2023.1258091/full

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