Flavones scaffold of Chromolaena odorata as a potential xanthine oxidase inhibitor: Induced Fit Docking and ADME studies

Flavones scaffold of Chromolaena odorata as a potential xanthine oxidase inhibitor: Induced Fit Docking and ADME studies

Introduction: Gout is a type of painful inflammation initiated by the interactions between monosodium urate crystals and connective tissue. Xanthine oxidase (XO) catalyzes the oxidation of hypoxanthine to xanthine, then to uric acid. The primary treatments for gout include XO inhibitors. At present,...

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Bibliographic Details
Main Authors: Babatomiwa Kikiowo, Adewale Joseph Ogunleye, Olumide Kayode Inyang, Niyi Samuel Adelakun, Olaposi Idowu Omotuyi, Damilohun Samuel Metibemu, Temitope Israel David, Oluwatoyin Olajide Oludoyi, Taiwo Tolulope Ijatuyi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2020-09-01
Series:BioImpacts
Subjects:
adme
flavones scaffold
gout
induced fit docking
lipinski's rule of five
xanthine oxidase
Online Access:https://bi.tbzmed.ac.ir/PDF/bi-10-227.pdf

Internet

https://bi.tbzmed.ac.ir/PDF/bi-10-227.pdf

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