Treatment of Pheochromocytoma Cells with Recurrent Cycles of Hypoxia: A New Pseudohypoxic In Vitro Model

Treatment of Pheochromocytoma Cells with Recurrent Cycles of Hypoxia: A New Pseudohypoxic In Vitro Model

Continuous activation of hypoxia pathways in pheochromocytomas and paragangliomas (PPGLs) is associated with higher disease aggressiveness, for which effective treatment strategies are still missing. Most of the commonly used in vitro models lack characteristics of these pseudohypoxic tumors, includ...

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Bibliographic Details
Main Authors: Jana Helm, Stephan Drukewitz, Isabel Poser, Susan Richter, Markus Friedemann, Doreen William, Hermine Mohr, Svenja Nölting, Mercedes Robledo, Stefan R. Bornstein, Graeme Eisenhofer, Nicole Bechmann
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
hypoxia resistance
pseudohypoxia
metastasis
pheochromocytoma
paraganglioma
drug resistance
Online Access:https://www.mdpi.com/2073-4409/11/3/560

Internet

https://www.mdpi.com/2073-4409/11/3/560

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