Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration

Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration

Digital pathology is increasingly prominent in neurodegenerative disease research, but variability in immunohistochemical staining intensity between staining batches prevents large-scale comparative studies. Here we provide a statistically rigorous method to account for staining batch effects in a l...

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Bibliographic Details
Main Authors: Lucia A. A. Giannini, Sharon X. Xie, Claire Peterson, Cecilia Zhou, Edward B. Lee, David A. Wolk, Murray Grossman, John Q. Trojanowski, Corey T. McMillan, David J. Irwin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neuroscience
Subjects:
digital histopathology
frontotemporal lobar degeneration
pre-analytical variability
batch effects
linear transformation method
validation of a method
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00682/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.00682/full

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