A comprehensive approach to developing a multi-epitope vaccine against Mycobacterium tuberculosis: from in silico design to in vitro immunization evaluation

A comprehensive approach to developing a multi-epitope vaccine against Mycobacterium tuberculosis: from in silico design to in vitro immunization evaluation

IntroductionThe Bacillus Calmette-Guérin (BCG) vaccine, currently used against tuberculosis (TB), exhibits inconsistent efficacy, highlighting the need for more potent TB vaccines.Materials and methodsIn this study, we employed reverse vaccinology techniques to develop a promising multi-epitope vacc...

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Bibliographic Details
Main Authors: Fan Jiang, Yong Han, Yinping Liu, Yong Xue, Peng Cheng, Li Xiao, Wenping Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis (MTB)
tuberculosis (TB)
multi-epitope vaccine (MEV)
immunoinformatic
enzyme linked immunospot assay (ELISPOT)
cytometric bead assay (CBA)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1280299/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1280299/full

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