Decitabine Induces Change of Biological Traits in Myelodysplastic Syndromes via FOXO1 Activation

Decitabine Induces Change of Biological Traits in Myelodysplastic Syndromes via FOXO1 Activation

Decitabine (DAC) is considered to be a profound global DNA demethylation, which can induce the re-expression of silenced tumor suppressor genes. Little is known about the function of tumor suppressor gene FOXO1 in myelodysplastic syndromes (MDS). To address this issue, the study firstly investigated...

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Bibliographic Details
Main Authors: Zheng Zhang, Yan Jia, Feng Xv, Lu-xi Song, Lei Shi, Juan Guo, Chun-kang Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Genetics
Subjects:
myelodysplastic syndromes
DEGs
FOXO1
PTEN
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.603956/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2020.603956/full

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