Receptor tyrosine kinase structure and function in health and disease

Receptor tyrosine kinase structure and function in health and disease

Receptor tyrosine kinases (RTKs) are membrane proteins that control the flow of information through signal transduction pathways, impacting on different aspects of cell function. RTKs are characterized by a ligand-binding ectodomain, a single transmembrane α-helix, a cytosolic region comprising juxt...

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Bibliographic Details
Main Authors: Oleg A. Karpov, Gareth W. Fearnley, Gina A. Smith, Jayakanth Kankanala, Michael J. McPherson, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
Format: Article
Language:English
Published: AIMS Press 2015-09-01
Series:AIMS Biophysics
Subjects:
receptor tyrosine kinase
signal transduction
phosphorylation
membrane trafficking
proteolysis
development
cancer
disease
Online Access:http://www.aimspress.com/biophysics/article/423/fulltext.html

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http://www.aimspress.com/biophysics/article/423/fulltext.html

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