The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration

The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration

Summary: Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell recruitment are poorly understood. Plasmalemma-ve...

Full description

Bibliographic Details
Main Authors: Alex L. Wilkinson, Samuel Hulme, James I. Kennedy, Emily R. Mann, Paul Horn, Emma L. Shepherd, Kelvin Yin, Marco Y.W. Zaki, Gareth Hardisty, Wei-Yu Lu, Pia Rantakari, David H. Adams, Marko Salmi, Matthew Hoare, Daniel A. Patten, Shishir Shetty
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Microenvironment
Molecular biology
Cell biology
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223020436

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223020436

Similar Items