A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors

A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors

Specific signalling thresholds of the WNT/β-catenin pathway affect embryogenesis and tissue homeostasis in the adult, with mutations in this pathway frequently occurring in cancer. Excessive WNT/β-catenin activity inhibits murine anterior development associated with embryonic lethality and accounts...

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Bibliographic Details
Main Authors: Janson Tse, Ryan O’Keefe, Angela Rigopolous, Annalisa L. E. Carli, Jo Waaler, Stefan Krauss, Matthias Ernst, Michael Buchert
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biomedicines
Subjects:
WNT/β-catenin signalling
WNT inhibitors
in vivo assay
tankyrase inhibitor
pyrvinium pamoate
<i>APC</i>
Online Access:https://www.mdpi.com/2227-9059/11/10/2719

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https://www.mdpi.com/2227-9059/11/10/2719

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