Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects

Background: Immunogenicity refers to the inherent ability of a molecule to stimulate an immune response. Aggregates are one of the major risk factors for the undesired immunogenicity of therapeutic antibodies (Ab) and may ultimately result in immune-mediated adverse effects. For Ab delivered by inha...

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Autors principals: Thomas Sécher, Elsa Bodier-Montagutelli, Christelle Parent, Laura Bouvart, Mélanie Cortes, Marion Ferreira, Ronan MacLoughlin, Guy Ilango, Otmar Schmid, Renaud Respaud, Nathalie Heuzé-Vourc’h
Format: Article
Idioma:English
Publicat: MDPI AG 2022-03-01
Col·lecció:Pharmaceutics
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Accés en línia:https://www.mdpi.com/1999-4923/14/3/671