Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13554-y |
| _version_ | 1818842053148147712 |
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| author | Shunsuke Hasegawa Hotaka Fukushima Hiroshi Hosoda Tatsurou Serita Rie Ishikawa Tomohiro Rokukawa Ryouka Kawahara-Miki Yue Zhang Miho Ohta Shintaro Okada Toshiyuki Tanimizu Sheena A. Josselyn Paul W. Frankland Satoshi Kida |
| author_facet | Shunsuke Hasegawa Hotaka Fukushima Hiroshi Hosoda Tatsurou Serita Rie Ishikawa Tomohiro Rokukawa Ryouka Kawahara-Miki Yue Zhang Miho Ohta Shintaro Okada Toshiyuki Tanimizu Sheena A. Josselyn Paul W. Frankland Satoshi Kida |
| author_sort | Shunsuke Hasegawa |
| collection | DOAJ |
| description | The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation. |
| first_indexed | 2024-12-19T04:35:51Z |
| format | Article |
| id | doaj.art-58cfaf7133c44f2abb529a34f9248cd2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:35:51Z |
| publishDate | 2019-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-58cfaf7133c44f2abb529a34f9248cd22022-12-21T20:35:45ZengNature PortfolioNature Communications2041-17232019-12-0110111410.1038/s41467-019-13554-yHippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylationShunsuke Hasegawa0Hotaka Fukushima1Hiroshi Hosoda2Tatsurou Serita3Rie Ishikawa4Tomohiro Rokukawa5Ryouka Kawahara-Miki6Yue Zhang7Miho Ohta8Shintaro Okada9Toshiyuki Tanimizu10Sheena A. Josselyn11Paul W. Frankland12Satoshi Kida13Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureNODAI Genome Research Center, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureDepartment of Physiology, Faculty of Medicine, University of TorontoDepartment of Physiology, Faculty of Medicine, University of TorontoDepartment of Bioscience, Faculty of Applied Bioscience, Tokyo University of AgricultureThe neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.https://doi.org/10.1038/s41467-019-13554-y |
| spellingShingle | Shunsuke Hasegawa Hotaka Fukushima Hiroshi Hosoda Tatsurou Serita Rie Ishikawa Tomohiro Rokukawa Ryouka Kawahara-Miki Yue Zhang Miho Ohta Shintaro Okada Toshiyuki Tanimizu Sheena A. Josselyn Paul W. Frankland Satoshi Kida Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation Nature Communications |
| title | Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation |
| title_full | Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation |
| title_fullStr | Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation |
| title_full_unstemmed | Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation |
| title_short | Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation |
| title_sort | hippocampal clock regulates memory retrieval via dopamine and pka induced glua1 phosphorylation |
| url | https://doi.org/10.1038/s41467-019-13554-y |
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