The mTOR inhibitor Rapamycin protects from premature cellular senescence early after experimental kidney transplantation

The mTOR inhibitor Rapamycin protects from premature cellular senescence early after experimental kidney transplantation

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Interstitial fibrosis and tubular atrophy, a major cause of kidney allograft dysfunction, has been linked to premature cellular senescence. The mTOR inhibitor Rapamycin protects from senescence in experimental models, but its antiproliferative properties have raised concern early after transplantati...

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Bibliographic Details
Main Authors: Uwe Hoff, Denise Markmann, Daniela Thurn-Valassina, Melina Nieminen-Kelhä, Zulrahman Erlangga, Jessica Schmitz, Jan Hinrich Bräsen, Klemens Budde, Anette Melk, Björn Hegner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022825/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022825/?tool=EBI

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