Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Abstract Background T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) and programmed cell death protein 1 (PD-1) are important inhibitory receptors that associate with T cell exhaustion in acute myeloid leukemia (AML). In this study, we aimed to determine...

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Bibliographic Details
Main Authors: Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Hematology & Oncology
Subjects:
Blimp-1
TIGIT
PD-1
T cell exhaustion
Acute myeloid leukemia (AML)
Online Access:http://link.springer.com/article/10.1186/s13045-017-0486-z

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http://link.springer.com/article/10.1186/s13045-017-0486-z

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