Insights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies

Insights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies

The human neural tube defects (NTD), anencephaly, spina bifida and craniorachischisis, originate from a failure of the embryonic neural tube to close. Human NTD are relatively common and both complex and heterogeneous in genetic origin, but the genetic variants and developmental mechanisms are large...

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Bibliographic Details
Main Authors: Diana M. Juriloff, Muriel J. Harris
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Journal of Developmental Biology
Subjects:
neural tube
neural folds
anencephaly
exencephaly
spina bifida
craniorachischisis
folate
epigenetics
developmental genetics
Online Access:http://www.mdpi.com/2221-3759/6/3/22

Internet

http://www.mdpi.com/2221-3759/6/3/22

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