Downregulation of Ambra1 by altered DNA methylation exacerbates dopaminergic neuron damage in a fenpropathrin-induced Parkinson-like mouse model

Downregulation of Ambra1 by altered DNA methylation exacerbates dopaminergic neuron damage in a fenpropathrin-induced Parkinson-like mouse model

Fenpropathrin (Fen), a volatile pyrethroid insecticide, is used widely for agricultural applications and has been reported to increase the risk of Parkinson’s disease (PD). However, the molecular basis, underlying mechanisms, and pathophysiology of Fen-exposed Parkinsonism remain unknown. Recent stu...

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Bibliographic Details
Main Authors: Songzhe He, Qi Qu, Xi Chen, Li Zhao, Zhigang Jiao, Zhiting Wan, Hang Fai Kwok, Shaogang Qu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Parkinson’s disease
Dopaminergic neuron
Fenpropathrin
Ambra1
Mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324000708

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http://www.sciencedirect.com/science/article/pii/S0147651324000708

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