Indoleamine 2,3 dioxygenase 1 immobilization on magnetic nanoparticles for screening inhibitors from coffee

Indoleamine 2,3 dioxygenase 1 immobilization on magnetic nanoparticles for screening inhibitors from coffee

In this study, a ligand fishing method was developed to screen potential indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors from coffee extracts by immobilization of IDO1 enzyme on amino-modified magnetic nanoparticles combined with UHPLC-Q-TOF-MS/MS analysis. Parameters including enzyme concentration,...

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Bibliographic Details
Main Authors: Zhuoting Liu, Yunfang Ping, Lumei Zhang, Jingran Zhang, Ann Van Schepdael, Xu Wang
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Food Chemistry: X
Subjects:
Immobilized IDO1
Ligand fishing
Magnetic nanoparticles
Molecular docking
Coffee
Online Access:http://www.sciencedirect.com/science/article/pii/S2590157523000330

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http://www.sciencedirect.com/science/article/pii/S2590157523000330

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