Unraveling EGFR-TKI resistance in lung cancer with high PD-L1 or TMB in EGFR-sensitive mutations

Unraveling EGFR-TKI resistance in lung cancer with high PD-L1 or TMB in EGFR-sensitive mutations

Abstract Background Although EGFR-TKI resistance mechanisms in non-small cell lung cancer (NSCLC) have been extensively studied, certain patient subgroups remain with unclear mechanisms. This retrospective study analysed mutation data of NSCLC patients with EGFR-sensitive mutations and high programm...

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Bibliographic Details
Main Authors: Wuwu Ding, Pengmin Yang, Xiaokai Zhao, Xiaozhi Wang, Huaqing Liu, Qing Su, Xintao Wang, Jieyi Li, Ziying Gong, Daoyun Zhang, Xinwei Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Respiratory Research
Subjects:
EGFR-TKIs
PD-L1
TMB
Resistance
PI3K signaling pathway
Online Access:https://doi.org/10.1186/s12931-023-02656-3

Internet

https://doi.org/10.1186/s12931-023-02656-3

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