Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor

Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor

CAR-T cells present a highly effective therapeutic option for several malignant diseases, based on their ability to recognize the selected tumor surface marker in an MHC-independent manner. This triggers cell activation and cytokine production, resulting in the killing of the cancerous cell presenti...

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Bibliographic Details
Main Authors: Duško Lainšček, Anja Golob-Urbanc, Veronika Mikolič, Jelica Pantović-Žalig, Špela Malenšek, Roman Jerala
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
CD19 CAR-T cells
cancer immunotherapy
heterodimerization system
pharmacological control
NFAT
artificial transcription factors
Online Access:http://www.sciencedirect.com/science/article/pii/S237277052300030X

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http://www.sciencedirect.com/science/article/pii/S237277052300030X

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