Shared and unique phosphoproteomics responses in skeletal muscle from exercise models and in hyperammonemic myotubes

Shared and unique phosphoproteomics responses in skeletal muscle from exercise models and in hyperammonemic myotubes

Summary: Skeletal muscle generation of ammonia, an endogenous cytotoxin, is increased during exercise. Perturbations in ammonia metabolism consistently occur in chronic diseases, and may blunt beneficial skeletal muscle molecular responses and protein homeostasis with exercise. Phosphorylation of sk...

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Bibliographic Details
Main Authors: Nicole Welch, Shashi Shekhar Singh, Ryan Musich, M. Shahid Mansuri, Annette Bellar, Saurabh Mishra, Aruna K. Chelluboyina, Jinendiran Sekar, Amy H. Attaway, Ling Li, Belinda Willard, Troy A. Hornberger, Srinivasan Dasarathy
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Biological sciences
Cell biology
Functional aspects of cell biology
Omics
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222015978

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222015978

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