Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca2+]i rise in embryonic motoneurons

Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca2+]i rise in embryonic motoneurons

Autoantibodies to the synaptic protein amphiphysin play a crucial pathogenic role in paraneoplastic stiff-person syndrome. Impairment of GABAergic inhibition is the presumed pathophysiological mechanism by which these autoantibodies become pathogenic. Here we used calcium imaging on rat embryonic mo...

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Bibliographic Details
Main Authors: C. Geis, M. Beck, S. Jablonka, A. Weishaupt, K.V. Toyka, M. Sendtner, C. Sommer
Format: Article
Language:English
Published: Elsevier 2009-10-01
Series:Neurobiology of Disease
Subjects:
Stiff person syndrome
Amphiphysin
Autoantibodies
Calcium imaging
Chloride potential
Na+/K+/2Cl2− cotransporter
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610900182X

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http://www.sciencedirect.com/science/article/pii/S096999610900182X

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