Ketamine Within Clinically Effective Range Inhibits Glutamate Transmission From Astrocytes to Neurons and Disrupts Synchronization of Astrocytic SICs

Ketamine Within Clinically Effective Range Inhibits Glutamate Transmission From Astrocytes to Neurons and Disrupts Synchronization of Astrocytic SICs

BackgroundAstrocytes are now considered as crucial modulators of neuronal synaptic transmission. General anesthetics have been found to inhibit astrocytic activities, but it is not clear whether general anesthetics within the clinical concentration range affects the astrocyte-mediated synaptic regul...

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Bibliographic Details
Main Authors: Yu Zhang, Sisi Wu, Liwei Xie, Shouyang Yu, Lin Zhang, Chengxi Liu, Wenjing Zhou, Tian Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ketamine
slow inward current
astrocyte
GluN2B receptor
neuromodulation
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00240/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00240/full

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