α-Synuclein A53T Promotes Mitochondrial Proton Gradient Dissipation and Depletion of the Organelle Respiratory Reserve in a Neuroblastoma Cell Line

α-Synuclein A53T Promotes Mitochondrial Proton Gradient Dissipation and Depletion of the Organelle Respiratory Reserve in a Neuroblastoma Cell Line

α-synuclein (αSyn) is a small neuronal protein whose accumulation correlates with Parkinson’s disease. αSyn A53T mutant impairs mitochondrial functions by affecting substrate import within the organelle, activity of complex I and the maximal respiratory capacity. However, the precise mechanism initi...

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Bibliographic Details
Main Authors: Pierpaolo Risiglione, Salvatore Antonio Maria Cubisino, Cristiana Lucia Rita Lipari, Vito De Pinto, Angela Messina, Andrea Magrì
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Life
Subjects:
αSyn
mitochondrial dysfunction
Parkinson’s disease
high-resolution respirometry
Online Access:https://www.mdpi.com/2075-1729/12/6/894

Internet

https://www.mdpi.com/2075-1729/12/6/894

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