Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice

Gender and sex differences in pain recognition and drug responses have been reported in clinical trials and experimental models of pain. Among antidepressants, contradictory results have been observed in patients treated with selective serotonin reuptake inhibitors (SSRIs). This study evaluated sex...

Full description

Bibliographic Details
Main Authors: Magda Zammataro, Sara Merlo, Massimo Barresi, Carmela Parenti, Huijuan Hu, Maria A. Sortino, Santina Chiechio
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
pain
fluoxetine
sex differences
metabotropic glutamate 2 receptor
HDAC2
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00743/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00743/full

Similar Items