Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer

Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer

Abstract Background Castration-resistant prostate cancer often metastasizes to the bone, and such bone metastases eventually become resistant to available therapies, leading to the death of patients. Enriched in the bone, TGF-β plays a pivotal role in bone metastasis development. However, directly t...

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Bibliographic Details
Main Authors: Qingqing Huang, Mingcheng Liu, Duo Zhang, Bing-Biao Lin, Xing Fu, Zhiqian Zhang, Baotong Zhang, Jin-Tang Dong
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Medicine
Subjects:
Prostate cancer
Bone metastasis
TGF-β
Acetylated-KLF5
Nitazoxanide
MYBL2
Online Access:https://doi.org/10.1186/s12916-023-02763-4

Internet

https://doi.org/10.1186/s12916-023-02763-4

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