PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis

PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis

Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics, such as oxaliplatin (L-OHP). The aim of the present work was to evaluate the potential beneficial effects of 2-pentadecyl-2-oxazoline (PEA-OXA) in a murine model of oxaliplatin-induced peripheral n...

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Bibliographic Details
Main Authors: Michela Campolo, Marika Lanza, Irene Paterniti, Alessia Filippone, Alessio Ardizzone, Giovanna Casili, Sarah A. Scuderi, Caterina Puglisi, Marzia Mare, Lorenzo Memeo, Salvatore Cuzzocrea, Emanuela Esposito
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
palmitoylethanolamide ultramicronized (PEAum)
2-pentadecyl-2-oxazoline (PEA-OXA)
oxaliplatin (L-OHP)
pain
dorsal root ganglia (DRG)
Online Access:https://www.mdpi.com/1422-0067/22/8/3927

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https://www.mdpi.com/1422-0067/22/8/3927

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