Effects of hypoxia on antigen presentation and T cell-based immune recognition of HPV16-transformed cells

Effects of hypoxia on antigen presentation and T cell-based immune recognition of HPV16-transformed cells

Attempts to develop a therapeutic vaccine against human papillomavirus (HPV)-induced malignancies have mostly not been clinically successful to date. One reason may be the hypoxic microenvironment present in most tumors, including cervical cancer. Hypoxia dysregulates the levels of human leukocyte a...

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Bibliographic Details
Main Authors: Nitya Mohan, Kathrin Wellach, Ceren Özerdem, Nisha Veits, Jonas D. Förster, Sophia Foehr, Maria Bonsack, Angelika B. Riemer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
Hypoxia
human papillomavirus (HPV)
antigen processing and presentation machinery (APM)
cytotoxic T cells
tumor microenvironment (TME)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.918528/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.918528/full

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