Analysis of gene expression levels and their impact on survival in 31 cancer-types patients identifies novel prognostic markers and suggests unexplored immunotherapy treatment options in a wide range of malignancies

Analysis of gene expression levels and their impact on survival in 31 cancer-types patients identifies novel prognostic markers and suggests unexplored immunotherapy treatment options in a wide range of malignancies

Abstract Background Immunotherapy has dramatically improved cancer treatment by inhibiting or activating specific cell receptors, thus unleashing the host anti-tumor response. However, the engagement of the three main immune checkpoints so far identified, CTLA4, PD-1 and PD-L1, is effective in a fra...

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Bibliographic Details
Main Authors: Claudia Giampietri, Francesca Scatozza, Elena Crecca, Virginia Vigiano Benedetti, Pier Giorgio Natali, Antonio Facchiano
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Translational Medicine
Subjects:
Melanoma
Cholangiocarcinoma
Thymoma
Testis cancer
LAG3
TIM3
Online Access:https://doi.org/10.1186/s12967-022-03670-7

Internet

https://doi.org/10.1186/s12967-022-03670-7

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