Analysis of Vipadenant and Its In Vitro and In Vivo Metabolites via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

Analysis of Vipadenant and Its In Vitro and In Vivo Metabolites via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry

A simple and sensitive liquid chromatography⁻quadrupole-time-of-flight⁻mass spectrometric (LC-QTOF-MS) assay has been developed for the evaluation of drug metabolism and pharmacokinetics (PK) properties of vipadenant in rat, a selective A2a receptor antagonist as one of the novel...

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Bibliographic Details
Main Authors: Seok-Ho Shin, Min-Ho Park, Jin-Ju Byeon, Byeong ill Lee, Yuri Park, Nahye Kim, Jangmi Choi, Young G. Shin
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
vipadenant
A2a receptor antagonist
immune checkpoint
LC-QTOF-MS
metabolite identification
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/10/4/260

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https://www.mdpi.com/1999-4923/10/4/260

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