Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway

Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway

Background: The omnipresence of human phthalate (PAE) exposure is linked to various adverse health issues, including breast cancer. However, the effects of low-dose PAE exposure on breast cancer stem cells (BCSCs) and the underlying mechanism remain unexplored. Methods: BCSCs from breast cancer cell...

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Bibliographic Details
Main Authors: Wan-shuang Cao, Meng-jiu Zhao, Yue Chen, Jian-yun Zhu, Chun-feng Xie, Xiao-ting Li, Shan-shan Geng, Cai-yun Zhong, Jin-yan Fu, Jie-shu Wu
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Breast cancer stem cells
Phthalates
Sonic hedgehog pathway
ΔNp63α
Low dose
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323001094

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http://www.sciencedirect.com/science/article/pii/S0147651323001094

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