Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-<i>O</i>-methylation of ribosomal RNAs (rRNAs), a modification essential for accurate...

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Bibliographic Details
Main Authors: Yun Shi, Ibrahim M. El-Deeb, Veronika Masic, Lauren Hartley-Tassell, Andrea Maggioni, Mark von Itzstein, Thomas Ve
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
methyltransferase
S-adenosyl methionine
cofactor
fragment screening
inhibitors
Online Access:https://www.mdpi.com/1424-8247/15/1/26

Internet

https://www.mdpi.com/1424-8247/15/1/26

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