WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome

WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome

Abstract Background Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) and in vivo (zebrafish). Moreover, WRN depletion ca...

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Bibliographic Details
Main Authors: Yuyao Tian, Sofie Lautrup, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Wai-Yee Chan
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell & Bioscience
Subjects:
Werner syndrome
WRN
Abnormal metabolism
SMARCA5
Online Access:https://doi.org/10.1186/s13578-023-01183-4

Internet

https://doi.org/10.1186/s13578-023-01183-4

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