WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome
Abstract Background Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) and in vivo (zebrafish). Moreover, WRN depletion ca...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2024-01-01
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Series: | Cell & Bioscience |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13578-023-01183-4 |