A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach.

A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach.

Since the advent of genome-wide small interfering RNA screening, large numbers of cellular cofactors important for viral infection have been discovered at a rapid pace, but the viral targets and the mechanism of action for many of these cofactors remain undefined. One such cofactor is cyclophilin A...

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Bibliographic Details
Main Authors: Feng Yang, Jason M Robotham, Henry Grise, Stephen Frausto, Vanesa Madan, Margarita Zayas, Ralf Bartenschlager, Margaret Robinson, Andrew E Greenstein, Anita Nag, Timothy M Logan, Ewa Bienkiewicz, Hengli Tang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2944805?pdf=render

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http://europepmc.org/articles/PMC2944805?pdf=render

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