Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects

Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly mediated by two exotoxins: toxin A (TcdA) and toxin B (TcdB). These toxins primarily disrupt the cytoskeletal struct...

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Bibliographic Details
Main Authors: Stefano Di Bella, Paolo Ascenzi, Steven Siarakas, Nicola Petrosillo, Alessandra di Masi
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/8/5/134