Dual-Specificity Phosphatase 4 Overexpression in Cells Prevents Hypoxia/Reoxygenation-Induced Apoptosis via the Upregulation of eNOS

Dual-Specificity Phosphatase 4 Overexpression in Cells Prevents Hypoxia/Reoxygenation-Induced Apoptosis via the Upregulation of eNOS

Mitogen-activated protein kinases (MAPKs) signaling cascades regulate several cellular functions, including differentiation, proliferation, survival, and apoptosis. The duration and magnitude of phosphorylation of these MAPKs are decisive determinants of their physiological functions. Dual-specifici...

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Bibliographic Details
Main Authors: Chun-An Chen, Julie A. Dougherty, Joanna Kilbane Myers, Mahmood Khan, Mark G. Angelos
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
dual-specificity phosphatase 4
reactive oxygen species
mitogen-activated protein kinases
eNOS
Nox4
S-glutathionylation
Online Access:http://journal.frontiersin.org/article/10.3389/fcvm.2017.00022/full

Internet

http://journal.frontiersin.org/article/10.3389/fcvm.2017.00022/full

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