Hypoxia inhibits osteoclast differentiation by HIF-1α-mediated upregulation of NRP-1

Hypoxia inhibits osteoclast differentiation by HIF-1α-mediated upregulation of NRP-1

Objective To investigate the regulation effect of hypoxic/HIF-1α pathway on the differentiation of RAW264.7 cells into mature osteoclasts, and to explore the possible molecular mechanism. Methods RAW264.7 cell lines with stable low expression of HIF-1α and NRP-1 were respectively established by shor...

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Bibliographic Details
Main Authors: LI Songtao, SUN Jing, CHEN Wugui, MA Min, ZHANG Ying
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2019-06-01
Series:Di-san junyi daxue xuebao
Subjects:
hif-1α
nrp-1
hypoxia
osteoclast differentiation
raw 264.7 cells
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/201811206.htm

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http://aammt.tmmu.edu.cn/Upload/rhtml/201811206.htm

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