Extracellular Vesicle-Packaged miR-195-5p Sensitizes Melanoma to Targeted Therapy with Kinase Inhibitors

Extracellular Vesicle-Packaged miR-195-5p Sensitizes Melanoma to Targeted Therapy with Kinase Inhibitors

Management of advanced melanoma remains challenging, with most BRAF (B-Raf proto-oncogene, serine/threonine kinase)-mutated metastatic patients relapsing within a few months upon MAPK inhibitors treatment. Modulation of tumor-derived extracellular vesicle (EVs) cargo with enrichment of antitumoral m...

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Bibliographic Details
Main Authors: Nathalia L. Santos, Silvina O. Bustos, Patricia P. Reis, Roger Chammas, Luciana N. S. Andrade
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
melanoma
miR-195-5p
extracellular vesicles
MAPK inhibitors
Online Access:https://www.mdpi.com/2073-4409/12/9/1317

Internet

https://www.mdpi.com/2073-4409/12/9/1317

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