OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

8-oxoguanine DNA glycosylase (OGG1) is the main DNA glycosylase responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from duplex DNA to initiate base excision repair. This glycosylase activity is relevant in many pathological conditions including cancer, inflammation, and neurodegenerat...

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Bibliographic Details
Main Authors: Bishoy M. F. Hanna, Thomas Helleday, Oliver Mortusewicz
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biomolecules
Subjects:
DNA oxidative damage
base excision repair
TH5487
OGG1 glycosylase inhibitor
chromatin dynamics
recruitment kinetics
Online Access:https://www.mdpi.com/2218-273X/10/11/1483

Internet

https://www.mdpi.com/2218-273X/10/11/1483

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