Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C

Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C

NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic receptor family, regulating NK cell activity and determining...

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Bibliographic Details
Main Authors: Sarah Vollmers, Annabelle Lobermeyer, Annika Niehrs, Pia Fittje, Daniela Indenbirken, Jacqueline Nakel, Sanamjeet Virdi, Sebastien Brias, Timo Trenkner, Gabriel Sauer, Sven Peine, Georg M.N. Behrens, Clara Lehmann, Anja Meurer, Ramona Pauli, Nils Postel, Julia Roider, Stefan Scholten, Christoph D. Spinner, Christoph Stephan, Eva Wolf, Christoph Wyen, Laura Richert, Paul J. Norman, Jürgen Sauter, Alexander H. Schmidt, Angelique Hoelzemer, Marcus Altfeld, Christian Körner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
NK cell
KIR
HLA-C
HIV-1
Vpu
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.922252/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.922252/full

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