Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis

Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis

Scopularide A is a promising potent anticancer lipopeptide isolated from a marine derived Scopulariopsis brevicaulis strain. The compound consists of a reduced carbon chain (3-hydroxy-methyldecanoyl) attached to five amino acids (glycine, l-valine, d-leucine, l-alanine, and l-phenylalanine). Using...

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Bibliographic Details
Main Authors: Mie Bech Lukassen, Wagma Saei, Teis Esben Sondergaard, Anu Tamminen, Abhishek Kumar, Frank Kempken, Marilyn G. Wiebe, Jens Laurids Sørensen
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Marine Drugs
Subjects:
non-ribosomal peptide synthetases
polyketide synthases
secondary metabolites
transcription factor
Fusarium
regulation
marine fungi
Online Access:http://www.mdpi.com/1660-3397/13/7/4331

Internet

http://www.mdpi.com/1660-3397/13/7/4331

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