Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking

Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking

Spastic paraplegia type 11 (SPG11) is a common autosomal recessive form of hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor neuron axons, leading to muscle spasticity and weakness. Impaired lipid trafficking is an emerging pathology in neurodegenerative disease...

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Bibliographic Details
Main Authors: Eric Chai, Zhenyu Chen, Yongchao Mou, Gitika Thakur, Weihai Zhan, Xue-Jun Li
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Neurobiology of Disease
Subjects:
Hereditary spastic paraplegias
Axonal degeneration
Cortical projection neuron
Human pluripotent stem cells
Cholesterol intracellular trafficking
LXR agonist
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612300308X

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http://www.sciencedirect.com/science/article/pii/S096999612300308X

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