Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02.

Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02.

Plasmodium falciparum Apical Membrane Antigen 1 (PfAMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies.We assessed the safety and immunogenicity of recombinant PfAMA1 in a dose-e...

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Bibliographic Details
Main Authors: Meta Roestenberg, Ed Remarque, Erik de Jonge, Rob Hermsen, Hildur Blythman, Odile Leroy, Egeruan Imoukhuede, Soren Jepsen, Opokua Ofori-Anyinam, Bart Faber, Clemens H M Kocken, Miranda Arnold, Vanessa Walraven, Karina Teelen, Will Roeffen, Quirijn de Mast, W Ripley Ballou, Joe Cohen, Marie Claude Dubois, Stéphane Ascarateil, Andre van der Ven, Alan Thomas, Robert Sauerwein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2602972?pdf=render

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http://europepmc.org/articles/PMC2602972?pdf=render

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