Bioinformatics Data Mining Repurposes the JAK2 (Janus Kinase 2) Inhibitor Fedratinib for Treating Pancreatic Ductal Adenocarcinoma by Reversing the <i>KRAS</i> (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-Driven Gene Signature

Bioinformatics Data Mining Repurposes the JAK2 (Janus Kinase 2) Inhibitor Fedratinib for Treating Pancreatic Ductal Adenocarcinoma by Reversing the <i>KRAS</i> (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-Driven Gene Signature

Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive and lethal cancer types due to the late diagnosis, high metastatic potential, and drug resistance. The development of novel therapeutic strategies is urgently needed. <i>KRAS</i> (Kirsten rat sarcoma 2 viral onco...

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Bibliographic Details
Main Authors: Li-Wei Liu, Yao-Yu Hsieh, Pei-Ming Yang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Journal of Personalized Medicine
Subjects:
bioinformatics
drug repurposing
gene signature
histone deacetylase inhibitor
pancreatic ductal adenocarcinoma
Online Access:https://www.mdpi.com/2075-4426/10/3/130

Internet

https://www.mdpi.com/2075-4426/10/3/130

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