Cyclosporin A protects JEG-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and JNK/p38 signaling pathways

Cyclosporin A protects JEG-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and JNK/p38 signaling pathways

Abstract Background Trophoblast cells are required for the establishment of pregnancy and fetal development. Apoptosis is an essential feature for trophoblast invasion. Uncontrolled trophoblast apoptosis is related to some complicate pregnancies. Oxidative stress (OS) is an important inducer of trop...

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Bibliographic Details
Main Authors: Bin He, Qi Yue Li, Yuan Yuan Wu, Jing Ling Ruan, Xiao Ming Teng, Da Jin Li, Chuan Ling Tang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Reproductive Biology and Endocrinology
Subjects:
Apoptosis
Oxidative stress
Trophoblast
p53
MAPK
Online Access:http://link.springer.com/article/10.1186/s12958-020-00658-0

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http://link.springer.com/article/10.1186/s12958-020-00658-0

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