Endoplasmic reticulum-quality control pathway and endoplasmic reticulum-associated degradation mechanism regulate the N-glycoproteins and N-glycan structures in the diatom Phaeodactylum tricornutum

Endoplasmic reticulum-quality control pathway and endoplasmic reticulum-associated degradation mechanism regulate the N-glycoproteins and N-glycan structures in the diatom Phaeodactylum tricornutum

Abstract Tunicamycin inhibits the first step of protein N-glycosylation modification. However, the physiological, transcriptomic, and N-glycomic effects of tunicamycin on important marine diatom Phaeodactylum tricornutum are still unknown. In this study, comprehensive approaches were used to study t...

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Bibliographic Details
Main Authors: Jichen Chen, Hong Du, Zidong Liu, Tangcheng Li, Hua Du, Wanna Wang, Muhammad Aslam, Weizhou Chen, Ping Li, Haodong Luo, Hao Fang, Xiaojuan Liu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Microbial Cell Factories
Subjects:
Tunicamycin
N-glycosylation modification
ER-quality control
ER-associated degradation
N-glycan
Phaeodactylum tricornutum
Online Access:https://doi.org/10.1186/s12934-022-01941-y

Internet

https://doi.org/10.1186/s12934-022-01941-y

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